Multi-residue analysis of Pharmaceutics and Personal Care Products (PPCPs) in aquatic environment by liquid chromatography tandem mass spectrometry

India Section of AOAC INTERNATIONAL Webinar Series

Join our webinar on September 15^th 2016 at 3 pm IST

Topic: Multi-residue analysis of Pharmaceutics and Personal Care Products (PPCPs) in aquatic environment by liquid chromatography tandem mass spectrometry

Speakers

Dr. Pranav Nagarnaik is a Scientist in CSIR-National Environmental Engineering Research Institute (CSIR-NEERI), Nagpur. He holds a M.S. from Syracuse University, USA and Ph.D. in Environmental Engineering from Texas A&M University, USA. His area of expertise is in method development, identification / quantification and fate of Pharmaceuticals and Personal Care Products (PPCPs) and Endocrine Disrupting Compounds (EDCs) in the environment. He has worked with US – Environmental Protection Agency (US-EPA) for mapping of 110 PPCPs and EDCs in hospital wastewater. He is currently working on detection and fate of compounds from plant origin in the Himalayan Rivers like Ganga & Yamuna. He is also working on technology development for providing sustainable clean water, development of water safety plans for small and large piped distribution networks and quantitative risk assessment through QMRA & QCRA approaches. He is a recipient of Joseph A. Orr Fellowship.

Akanksha Singh Kachhawaha is working as a Senior Research Fellow in CSIR-National Environmental Engineering Institute (CSIR-NEERI), Nagpur. She has completed her MSc in Forensic Science from Sagar University and currently pursuing her doctoral degree through Academy of Scientific and Innovative Research (AcSIR). Her research focuses on occurrence of Pharmaceuticals and personal care products in the aquatic environment and risk to microalgae. She has developed a sensitive multiresidue method to simultaneously determine PPCPs of diverse physico-chemical properties with the help of liquid chromatography and tandem mass spectrometry. Her research interest is on development of novel LC-MS/MS methods for emerging compounds, their metabolites and transformation products in aquatic environment to create a baseline data for the unregulated emerging contaminants. She is currently involved in monitoring PPCPs in Indian rivers and also working to monitor PPCPs in Indian river and to assess the toxicological risk to freshwater microalgae.

ABSTRACT

Multi-residue analysis of Pharmaceutics and Personal Care Products (PPCPs) in aquatic environment by liquid chromatography tandem mass spectrometry

In recent years, the ubiquity of pharmaceuticals and personal care products (PPCPs) in water bodies is a matter of worldwide concern. The development of antibiotic resistant microbes and endocrine disruption are the two major health adversities caused by PPCPs. Often, wastewater treatment plants fail to remove PPCPs, leading to the intrusion of PPCPs in the aquatic environment. Previous studies have shown that PPCPs are present at parts-per-trillion (PPT) levels in rivers and tributaries. Also, the reuse of treated wastewater for irrigation can cause potential accumulation of PPCPs in plants. In view of the above scenario, analysis of PPCPs is of utmost significance. In order to examine the occurrence and fate of these trace level emerging contaminants, efforts should be made to develop accurate, robust and sensitive multiresidue analytical methods.

This presentation will draw attention to a recently developed multiresidue liquid chromatography and tandem mass spectrometry method for simultaneous detection of multiclass PPCPs with diverse physico-chemical properties. It will briefly describe the developed solid phase extraction method and functionalisation of HLB (hydrophilic-lipophilic balanced) cartridges for the retention of extremely polar compounds. Evaluation of QuEChERS concept based approach and its comparison with the most commonly used SPE procedure for the extraction of PPCPs from water, will also be covered. In addition, it will highlight the major accomplishments of the developed method: reduced chromatographic run time, drastically minimised sample size, successful application of the method for extraction of PPCPs from water, low method detection limits (MDLs) and method quantification limits (MQLs).