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Webinar on Theory Overview Method Development approach for LCMS/MS & GCMS/MS
Chandrasekar Kandaswamy (Senior Scientist – GC/MS, Agilent Technologies)
Prasanth Joseph (Application Engineer-LC-MS, Agilent Technologies)
Gas chromatography (GC) and liquid chromatography (LC) are essential analytical instrumentation tools in modern food and environmental laboratories. A gas chromatograph equipped with element-selective detectors or mass spectrometry (MS) has traditionally been the method of choice for residue and contaminant analysis.
Recently Quadruple tandem mass spectrometry has gained popularity for quantitation due to its high selectivity and sensitivity in multiple reaction monitoring (MRM) mode. MRM works like a double mass filter and thus very little noise and matrix interferences are detected. This high selectivity typically results in improved limits of detection and quantitation and simplifies sample preparation.
Understanding basic of instrumentation, optimizing instrumentation parameters will be key for analyst to deliver accurate results and extending chromatographic performance.
This presentation is covering the following topics :
- principle of mass spectrometry
- Single and Triple quadruple
- Tuning and optimization of mass spectrometry parameters
- MRM method development
- MRM ratio
- Selective measurement technique